What the FDA labels say about taking them together
Sacubitril/valsartan and trandolapril
Trandolapril's FDA label of October 31, 2025 names sacubitril/valsartan in its contraindications section; sacubitril/valsartan's label does not name trandolapril itself but warns about its class (ACE inhibitors). The trandolapril label: “Do not administer trandolapril tablets within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS ).”
Check it at the source: the sacubitril/valsartan FDA label on DailyMed (effective July 6, 2026, Novartis Pharmaceuticals Corporation); the trandolapril FDA label on DailyMed (effective October 31, 2025, Lupin Pharmaceuticals, Inc.).
What does the sacubitril/valsartan label say about trandolapril?
Sacubitril/valsartan's label does not name trandolapril itself; it warns about its class (ACE inhibitors):
Sacubitril/valsartan label, contraindicationsCONTRAINDICATIONS ENTRESTO is contraindicated: in patients with hypersensitivity to any component in patients with a history of angioedema related to previous ACE inhibitor or ARB therapy [see Warnings and Precautions (5.2)] with concomitant use of ACE inhibitors.
Sacubitril/valsartan label, drug interactionsBlockade of the Renin-Angiotensin-Aldosterone System Concomitant use of ENTRESTO with an ACE inhibitor is contraindicated because of the increased risk of angioedema [see Contraindications (4)].
Source: FDA drug label (ENTRESTO), Novartis Pharmaceuticals Corporation, effective July 6, 2026 (SPL set 000dc81d-ab91-450c-8eae-8eb74e72296f), via openFDA; the full label on DailyMed
What does the trandolapril label say about sacubitril/valsartan?
Trandolapril label, contraindicationsDo not administer trandolapril tablets within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS ).
Source: FDA drug label (Trandolapril), Lupin Pharmaceuticals, Inc., effective October 31, 2025 (SPL set 8143a6cf-dadc-4ef7-a8db-d16d7150ad34), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sacubitril/valsartan | Trandolapril | |
|---|---|---|
| Labeled for | Heart failure | High blood pressure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.533 per unit 49-51 mg | $0.157 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once