What the FDA labels say about taking them together
Romidepsin and warfarin
Romidepsin's FDA label of January 31, 2023 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name romidepsin. The romidepsin label: “Carefully monitor prothrombin time (PT) and International Normalized Ratio (INR) in patients concurrently administered ISTODAX and warfarin or coumarin derivatives.”
Check it at the source: the romidepsin FDA label on DailyMed (effective January 31, 2023, Celgene Corporation); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the romidepsin label say about warfarin?
Romidepsin label, drug interactionsCarefully monitor prothrombin time (PT) and International Normalized Ratio (INR) in patients concurrently administered ISTODAX and warfarin or coumarin derivatives ( 7.1 ).
Source: FDA drug label (ISTODAX), NDA022393 (Bristol-Myers), as published by Celgene Corporation, effective January 31, 2023 (SPL set 03b39d40-90fe-11df-9de6-0002a5d5c51b), via openFDA; the full label on DailyMed
What does the warfarin label say about romidepsin?
Warfarin's label (effective May 29, 2026) does not name romidepsin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Romidepsin | Warfarin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once