Rolapitant and Digoxin Interaction
Drug interaction information between Rolapitant and Digoxin.
Rolapitant and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rolapitant and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant interferes with a protein pump that moves digoxin out of your body, leading to higher amounts of the heart medicine in your blood.
FDA Label Information
digoxin) Clinical Impact: Increased plasma concentrations of P-gp substrates (e.g., digoxin) may result in potential adverse reactions [see Clinical Pharmacology (12.3) ]. Intervention: Monitor digoxin concentrations with concomitant use of VARUBI and adjust the dosage as needed to maintain therapeutic concentrations.
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Rolapitant's 9. In the minor band specifically: Rolapitant has 6 (also Rosuvastatin, Warfarin, Methotrexate, Dextromethorphan); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Rolapitant and Digoxin?
Rolapitant interferes with a protein pump that moves digoxin out of your body, leading to higher amounts of the heart medicine in your blood.
Digoxin's labeled portfolio outnumbers Rolapitant
SPL source-record counts only. This page's band is minor · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Digoxin (Cardiac Glycoside).
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Rolapitant
- Rosuvastatin
- Warfarin
- Methotrexate
- Dextromethorphan
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.