What the FDA labels say about taking them together
Rilpivirine and voriconazole
Rilpivirine's FDA label of August 28, 2025 names voriconazole in its drug interactions section; the voriconazole labels PlainMeds reads (3) do not name rilpivirine. The rilpivirine label: “Concomitant use of EDURANT or EDURANT PED with azole antifungal agents may cause an increase in the plasma concentrations of rilpivirine. …”
Check it at the source: the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the rilpivirine label say about voriconazole?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Azole Antifungal Agents: fluconazole itraconazole ketoconazole This interaction study has been performed with a dose higher than the recommended dose for EDURANT assessing the maximal effect on the coadministered drug. The dosing recommendation is applicable to the recommended doses of EDURANT once daily. posaconazole voriconazole; Effect on Concentration of Rilpivirine or Concomitant Drug: ↑ rilpivirine ↓ ketoconazole; Clinical Comment: Concomitant use of EDURANT or EDURANT PED with azole antifungal agents may cause an increase in the plasma concentrations of rilpivirine (inhibition of CYP3A enzymes). …
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
What does the voriconazole label say about rilpivirine?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rilpivirine | Voriconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $48.04 per tablet 25 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once