What the FDA labels say about taking them together
Rilonacept and warfarin
Rilonacept's FDA label of December 16, 2025 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name rilonacept. The rilonacept label: “This is clinically relevant for CYP450 substrates with a narrow therapeutic index, where the dose is individually adjusted (e.g., warfarin).”
Check it at the source: the rilonacept FDA label on DailyMed (effective December 16, 2025); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the rilonacept label say about warfarin?
Rilonacept label, drug interactionsThis is clinically relevant for CYP450 substrates with a narrow therapeutic index, where the dose is individually adjusted (e.g., warfarin).
Source: FDA drug label (Arcalyst), Kiniksa Pharmaceuticals (UK), Ltd., effective December 16, 2025 (SPL set ad965f38-dd22-4607-a673-2fb92f3b527a), via openFDA; the full label on DailyMed
What does the warfarin label say about rilonacept?
Warfarin's label (effective May 29, 2026) does not name rilonacept in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rilonacept | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once