What the FDA labels say about taking them together
Rifabutin and tenofovir alafenamide
Rifabutin's FDA label of September 1, 2026 names tenofovir alafenamide in its drug interactions section, and tenofovir alafenamide's label names rifabutin too. The tenofovir alafenamide label: “Coadministration of VEMLIDY with rifabutin, rifampin or rifapentine is not recommended.”
Check it at the source: the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.); the tenofovir alafenamide FDA label on DailyMed (effective July 14, 2025, Gilead Sciences, Inc.).
What does the rifabutin label say about tenofovir alafenamide?
Rifabutin label, drug interactionsCo-administered drug: Bictegravir; Dosing regimen of co-administered drug: 75 mg once a day; Dosing regimen of rifabutin: 300 mg once a day (fasted); Study population (n): Healthy subjects; Effect on rifabutin: ND; Effect on co-administered drug: ↓ AUC 38% ↓ C min 56% ↓ C max 20%; Recommendation: Co-administration of rifabutin with Biktarvy (bictegravir/emtricitabine/ tenofovir alafenamide) is not recommended due to an expected decrease in tenofovir alafenamide in addition to the reported reduction in bictegravir. Refer to Biktarvy prescribing information for additional information.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
What does the tenofovir alafenamide label say about rifabutin?
Tenofovir alafenamide label, drug interactionsConcomitant Drug Class/Drug Name: Antimycobacterials:; Effect on Concentration ↓ = decrease.: ↓ tenofovir alafenamide; Clinical Comment: Coadministration of VEMLIDY with rifabutin, rifampin or rifapentine is not recommended.
Source: FDA drug label (VEMLIDY), Gilead Sciences, Inc., effective July 14, 2025 (SPL set 72e6b33c-0351-4070-9172-eeaa186c01d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifabutin | Tenofovir alafenamide | |
|---|---|---|
| Labeled for | n/a | Hepatitis B |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $8.14 per capsule 150 mg capsule | $51.98 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once