Repaglinide and Olanzapine Interaction
Drug interaction information between Repaglinide and Olanzapine.
Repaglinide and Olanzapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Repaglinide and Olanzapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Olanzapine can cause blood sugar levels to rise, which works against the effects of repaglinide.
FDA Label Information
Examples: Atypical antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Olanzapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Olanzapine has 26 labeled pairs on file vs Repaglinide's 22. In the minor band specifically: Repaglinide has 17 (also Albuterol, Fluoxetine, Montelukast, Ketoconazole); Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Carbamazepine).
What mechanism field is on file for Repaglinide and Olanzapine?
Olanzapine can cause blood sugar levels to rise, which works against the effects of repaglinide.
Repaglinide carries more major-labeled pairs than Olanzapine
SPL source-record counts only. This page's band is minor · classes on file: Repaglinide (Meglitinide); Olanzapine (Atypical Antipsychotic).
Repaglinide has 2 major-labeled pairs vs Olanzapine's 1. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Fluoxetine
- Montelukast
- Ketoconazole
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.