Repaglinide · more major-labeled pairs than Clopidogrel
SPL labels Repaglinide + Clopidogrel as minor; Repaglinide 17 / Clopidogrel 10 in that band.
Mechanism on file: Clopidogrel blocks the enzyme that breaks down repaglinide. This causes repaglinide levels to rise much higher than normal in your blood.
FDA SPL severity: Minor
Repaglinide + Clopidogrel · SPL mechanism field
Clopidogrel blocks the enzyme that breaks down repaglinide. This causes repaglinide levels to rise much higher than normal in your blood.
Minor band excerpt · Repaglinide with Clopidogrel
( 7.7 ) Repaglinide (CYP2C8 substrates): Increases substrate plasma concentrations. 7.8 Repaglinide (CYP2C8 Substrates) The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8. Clopidogrel increased repaglinide exposures by 3.9-fold to 5.1-fold [see Clinical Pharmacology (12.3) ] .
Repaglinide · 2 major-labeled pairs (vs Clopidogrel's 0)
- Albuterol minor
- Clozapine minor
- Epinephrine minor
- Erythromycin minor
Clopidogrel · 10 minor + 19 total pairs
- Bupropion minor
- Cannabidiol minor
- Dexlansoprazole minor
- Lansoprazole minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.