clopidogrel vs repaglinide
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of clopidogrel and repaglinide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.7 ) Repaglinide (CYP2C8 substrates): Increases substrate plasma concentrations. 7.8 Repaglinide (CYP2C8 Substrates) The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8. Clopidogrel increased repaglinide exposures by 3.9-fold to 5.1-fold [see Clinical Pharmacology (12.3) ] .
Plavix
Prandin
Clopidogrel is a drug that helps to prevent blood clots. It is used to lower your risk of heart attack and stroke.
Repaglinide (Prandin) helps control blood sugar in adults with type 2 diabetes. It works best when used with diet and exercise.
Clopidogrel is used to prevent heart attack and stroke in adults. It is for people who have had a recent heart attack or stroke. It is also for people with peripheral arterial disease (poor circulation). Clopidogrel can also help people with chest pain or certain heart problems.
Repaglinide is used to lower blood sugar in adults with type 2 diabetes. It should be used along with a healthy diet and regular exercise. This medicine is not for people with type 1 diabetes or diabetic ketoacidosis.
Clopidogrel keeps blood platelets from sticking together and forming clots. It blocks a substance that causes platelets to clump. This helps blood flow more freely through your body.
Repaglinide helps your pancreas release insulin after you eat. Insulin helps move sugar from your blood into your cells. This lowers your blood sugar levels.
- • Bleeding
- • Low blood sugar
- • Upper respiratory infection
- • Headache
- • Sinus infection
- • Joint pain
- Dyspnoea 9,917
- Myocardial Infarction 9,459
- Fatigue 8,479
- Gastrointestinal Haemorrhage 8,202
- Nausea 7,881
- Hypoglycaemia 765
- Acute Kidney Injury 548
- Drug Interaction 418
- Diarrhoea 365
- Lactic Acidosis 364
This drug may not work well for people with certain genes. If you have two copies of a certain gene, clopidogrel may not prevent clots as well. Your doctor may consider a different medicine for you.
Repaglinide can cause low blood sugar (hypoglycemia). If you skip a meal, skip your dose of repaglinide to avoid low blood sugar. Do not use repaglinide with NPH-insulin. There is no proof that repaglinide lowers your risk of heart problems.
Tell your doctor if you are pregnant or plan to become pregnant. Clopidogrel may increase bleeding during labor and delivery. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Poorly controlled diabetes during pregnancy can harm both the mother and the baby. Repaglinide is not recommended while breastfeeding due to the risk of low blood sugar in the baby.
Also Compare, Nearby Drugs
Compare repaglinide with
How to Read This clopidogrel vs repaglinide Comparison
clopidogrel is classified in the Antiplatelet Agent drug class, while repaglinide sits within the Meglitinide class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clopidogrel has 43,938 submissions while repaglinide has 2,460. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to clopidogrel blocks the enzyme that breaks down repaglinide. this causes repaglinide levels to rise much higher than normal in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for clopidogrel or repaglinide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.