Remdesivir and Chloroquine Interaction
Drug interaction information between Remdesivir and Chloroquine.
Remdesivir and Chloroquine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Remdesivir and Chloroquine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Chloroquine can block the antiviral effects of remdesivir, making it less powerful at treating the virus. This interaction was discovered in laboratory tests.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Effects of Other Drugs on VEKLURY Due to potential antagonism based on data from cell culture experiments, concomitant use of VEKLURY with chloroquine phosphate or hydroxychloroquine sulfate is not recommended [see Warnings and Precautions (5.3) and Microbiology (12.4) ].
Chloroquine Also Interacts With
- Dapsone Topical moderate
- Hydroxychloroquine moderate
- Lidocaine Topical moderate
- Methylprednisolone minor
Frequently Asked Questions
What SPL severity band is on file for Remdesivir + Chloroquine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Chloroquine has 5 labeled pairs on file vs Remdesivir's 2. In the moderate band specifically: Remdesivir has 2 (also Hydroxychloroquine); Chloroquine has 4 (also Dapsone Topical, Hydroxychloroquine, Lidocaine Topical).
What mechanism field is on file for Remdesivir and Chloroquine?
Chloroquine can block the antiviral effects of remdesivir, making it less powerful at treating the virus. This interaction was discovered in laboratory tests.
Chloroquine's labeled portfolio outnumbers Remdesivir
SPL source-record counts only. This page's band is moderate · classes on file: Remdesivir (Nucleotide Analog (Antiviral)); Chloroquine (Antimalarial).
0 major · 2 moderate · 0 minor · 2 total
- Other moderate peers for Remdesivir
- Hydroxychloroquine
0 major · 4 moderate · 1 minor · 5 total
- Other moderate peers for Chloroquine
- Dapsone Topical
- Hydroxychloroquine
- Lidocaine Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.