Remdesivir and Hydroxychloroquine Interaction
Drug interaction information between Remdesivir and Hydroxychloroquine.
Remdesivir and Hydroxychloroquine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Remdesivir and Hydroxychloroquine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Hydroxychloroquine can interfere with how remdesivir works against the virus. This means the antiviral treatment might not be able to fight the infection effectively.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Effects of Other Drugs on VEKLURY Due to potential antagonism based on data from cell culture experiments, concomitant use of VEKLURY with chloroquine phosphate or hydroxychloroquine sulfate is not recommended [see Warnings and Precautions (5.3) and Microbiology (12.4) ].
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Heparin moderate
- Methotrexate minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Remdesivir + Hydroxychloroquine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydroxychloroquine has 7 labeled pairs on file vs Remdesivir's 2. In the moderate band specifically: Remdesivir has 2 (also Chloroquine); Hydroxychloroquine has 4 (also Chloroquine, Cimetidine, Heparin).
What mechanism field is on file for Remdesivir and Hydroxychloroquine?
Hydroxychloroquine can interfere with how remdesivir works against the virus. This means the antiviral treatment might not be able to fight the infection effectively.
Hydroxychloroquine's labeled portfolio outnumbers Remdesivir
SPL source-record counts only. This page's band is moderate · classes on file: Remdesivir (Nucleotide Analog (Antiviral)); Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Hydroxychloroquine
- Chloroquine
- Cimetidine
- Heparin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.