Ramipril and Digoxin Interaction
Drug interaction information between Ramipril and Digoxin.
Ramipril and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ramipril and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ramipril does not change the way this heart medicine works or how it is broken down by the body.
FDA Label Information
7.6 Other Neither ramipril nor its metabolites have been found to interact with food, digoxin, antacid, furosemide, cimetidine, indomethacin, and simvastatin.
Ramipril Also Interacts With
- Spironolactone moderate
- Telmisartan moderate
- Lithium moderate
- Amiloride moderate
- Simvastatin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Ramipril + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Ramipril's 11. In the minor band specifically: Ramipril has 7 (also Simvastatin, Furosemide, Propranolol, Warfarin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Ramipril and Digoxin?
Ramipril does not change the way this heart medicine works or how it is broken down by the body.
Digoxin carries more major-labeled pairs than Ramipril
SPL source-record counts only. This page's band is minor · classes on file: Ramipril (ACE Inhibitor); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Ramipril's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Ramipril
- Simvastatin
- Furosemide
- Propranolol
- Warfarin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.