What the FDA labels say about taking them together
Quetiapine and ziprasidone
Ziprasidone's FDA label of July 20, 2026 names quetiapine in its warnings and precautions section; quetiapine's label does not name ziprasidone itself but warns about its class (Atypical antipsychotics). The ziprasidone label: “The mean increase in QTc from baseline for ziprasidone ranged from approximately 9 to 14 msec greater than for four of the comparator drugs, but was approximately 14 msec less than the prolongation observed for …”
Check it at the source: the quetiapine FDA label on DailyMed (effective April 10, 2026, H2-Pharma, LLC); the ziprasidone FDA label on DailyMed (effective July 20, 2026, Apotex Corp.).
What does the quetiapine label say about ziprasidone?
Quetiapine's label does not name ziprasidone itself; it warns about its class (Atypical antipsychotics):
Quetiapine label, boxed warningINCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [see Warnings and Precautions (5.1) ].
Quetiapine label, boxed warningIncreased Mortality in Elderly Patients with Dementia-Related Psychosis •Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Source: FDA drug label (SEROQUEL), NDA020639 (Cheplapharm), as published by H2-Pharma, LLC, effective April 10, 2026 (SPL set 8ae62aaf-f8c5-417f-baac-0098369ca322), via openFDA; the full label on DailyMed
What does the ziprasidone label say about quetiapine?
Ziprasidone label, warnings and precautionsThe mean increase in QTc from baseline for ziprasidone ranged from approximately 9 to 14 msec greater than for four of the comparator drugs (risperidone, olanzapine, quetiapine, and haloperidol), but was approximately 14 msec less than the prolongation observed for thioridazine.
Source: FDA drug label (ziprasidone hydrochloride), Apotex Corp., effective July 20, 2026 (SPL set ccfd5ba2-7271-f3dd-4c98-7418c1a4b54a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Quetiapine | Ziprasidone | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | Bipolar disorder, Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.127 per tablet 300 mg tablet | $0.269 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once