What the FDA labels say about taking them together
Protriptyline and selegiline
Selegiline's FDA label of August 7, 2024 names protriptyline in its warnings section; protriptyline's label does not name selegiline itself but warns about its class (MAO inhibitors).
Check it at the source: the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC); the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.).
What does the protriptyline label say about selegiline?
Protriptyline's label does not name selegiline itself; it warns about its class (MAO inhibitors):
Protriptyline label, contraindicationsWhen it is desired to substitute protriptyline for a monoamine oxidase inhibitor, a minimum of 14 days should be allowed to elapse after the latter is discontinued.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
What does the selegiline label say about protriptyline?
Selegiline label, warningsAnother patient receiving protriptyline and selegiline developed tremors, agitation, and restlessness followed by unresponsiveness and death two weeks after selegiline was added.
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Protriptyline | Selegiline | |
|---|---|---|
| Labeled for | Depression | Parkinson's disease, Depression |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2.71 per tablet 10 mg tablet | $0.756 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once