What the FDA labels say about taking them together
Propafenone and propranolol
Propafenone's FDA label of September 1, 2025 names propranolol in its drug interactions section, and propranolol's label names propafenone too. The propranolol label: “Co-administration of propranolol increases the plasma concentrations of propafenone.”
Check it at the source: the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the propafenone label say about propranolol?
Propafenone label, drug interactionsConcomitant use of propafenone and propranolol in healthy subjects increased propranolol plasma concentrations at steady state by 113%.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
What does the propranolol label say about propafenone?
Propranolol label, drug interactionsCardiovascular Drugs Antiarrhythmics The AUC of propafenone is increased by more than 200% by co-administration of propranolol.
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), drug interactionsCo-administration of propranolol increases the plasma concentrations of propafenone.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Propafenone | Propranolol | |
|---|---|---|
| Labeled for | Atrial fibrillation | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.115 per tablet 150 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once