What the FDA labels say about taking them together
Prazosin and propranolol
Prazosin's FDA label of March 6, 2026 names propranolol in its drug interactions section, and propranolol's label names prazosin too. The propranolol label: “Alpha Blockers Prazosin has been associated with prolongation of first dose hypotension in the presence of beta-blockers.”
Check it at the source: the prazosin FDA label on DailyMed (effective March 6, 2026, Prasco Laboratories); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the prazosin label say about propranolol?
Prazosin label, drug interactionsDrug Interactions Prazosin hydrochloride capsules have been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol (see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories–propoxyphene, aspirin, indomethacin, and phenylbutazone.
Prazosin label, warningsHypotension may develop in patients given prazosin hydrochloride capsules who are also receiving a beta-blocker such as propranolol.
Source: FDA drug label (Prazosin Hydrochloride), NDA017442 (Pfizer), as published by Prasco Laboratories, effective March 6, 2026 (SPL set cbe89216-7dea-43d7-b12e-44ccfb69af3d), via openFDA; the full label on DailyMed
What does the propranolol label say about prazosin?
Propranolol label, drug interactionsAlpha Blockers Prazosin has been associated with prolongation of first dose hypotension in the presence of beta-blockers.
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), drug interactionsAlpha Blockers: Co-administration of beta-blockers with alpha-blocker (e.g., prazosin) has been associated with prolongation of first dose hypotension and syncope.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Prazosin | Propranolol | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0842 per capsule 1 mg capsule | $0.0493 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once