What the FDA labels say about taking them together

Epinephrine and propranolol

Epinephrine's FDA label of July 13, 2026 names propranolol in its drug interactions section, and propranolol's label names epinephrine too. The epinephrine label: “… potentiating pressor effects of epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as …”

Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).

What does the epinephrine label say about propranolol?

Epinephrine label, drug interactions
β-blockers, such as propranolol

Epipen label (Viatris Specialty LLC, February 15, 2023), drug interactions
Beta-Adrenergic Blockers The cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta- adrenergic blocking drugs, such as propranolol.

Adrenalin (Epinephrine In Sodium Chloride) label (Par Health USA, LLC, August 1, 2023), drug interactions
Drugs Potentiating Pressor Effects of Epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin 7.3.

Epinephrine label (BPI Labs, LLC, December 26, 2025), drug interactions
DRUG INTERACTIONS Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin Drugs potentiating arrhythmogenic effects of epinephrine Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.6) and Adverse Reactions (6) ]. …

Epinephrine label (BPI Labs, LLC, December 26, 2025), warnings and precautions
Treatment of arrhythmias consists of administration of a beta-adrenergic blocking drug (such as propranolol).

Source: FDA drug label (Epipen, NDA019430), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7560c201-9246-487c-a13b-6295db04274a), via openFDA

Source: FDA drug label (Adrenalin (Epinephrine In Sodium Chloride), NDA215875), Par Health USA, LLC, effective August 1, 2023 (SPL set 61b0e2a2-71ed-43d6-b1a7-36d2dae651b5), via openFDA

Source: FDA drug label (Epinephrine, NDA205029), BPI Labs, LLC, effective December 26, 2025 (SPL set db18519b-82a9-435b-85c7-a040d644f057), via openFDA

Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed

What does the propranolol label say about epinephrine?

Propranolol label, drug interactions
Inotropic Agents Patients on long-term therapy with propranolol may experience uncontrolled hypertension if administered epinephrine as a consequence of unopposed alpha-receptor stimulation.

Propranolol label, warnings
Pheochromocytoma Blocking only the peripheral dilator (beta) action of epinephrine with propranolol leaves its constrictor (alpha) action unopposed.

Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), warnings and precautions
Effectiveness of Epinephrine in Treating Anaphylaxis Beta-adrenergic blocker-treated patients treated with epinephrine for a severe anaphylactic reaction may be less responsive to the typical doses of epinephrine.

Hemangeol label (Pierre Fabre Pharmaceuticals, Inc., June 25, 2026), warnings and precautions
Hypersensitivity Beta-blockers will interfere with epinephrine used to treat serious anaphylaxis.

Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA

Source: FDA drug label (Hemangeol, NDA205410), Pierre Fabre Pharmaceuticals, Inc., effective June 25, 2026 (SPL set b6f9dd2a-632b-87eb-70f0-b2064d7ed48a), via openFDA

Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

16Epinephrine generic labelers

42Propranolol generic labelers

	Epinephrine	Propranolol
Labeled for	Asthma	High blood pressure, Angina, Atrial fibrillation, Migraine
Boxed warning	No	No
Pharmacy cost (NADAC)	$123.51 per unit 0.15 mg auto-injct	$0.0493 per tablet 20 mg tablet
Shortage now	A presentation being discontinued	In shortage

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Epinephrine: the full record
Propranolol: the full record
Check more medicines together: up to five at once