What the FDA labels say about taking them together
Promethazine and tramadol
Tramadol's FDA label (Tramadol Hydrochloride Extended-Release) of January 23, 2026 names promethazine in its warnings and precautions section; the promethazine label PlainMeds reads does not name tramadol. The tramadol label: “Selective serotonin re-uptake inhibitors, Tricyclic antidepressants (TCAs), and other tricyclic compounds, Other opioids, MAO inhibitors.”
Check it at the source: the promethazine FDA label on DailyMed (effective March 13, 2026, KVK-Tech, Inc.); the tramadol FDA label on DailyMed (effective March 5, 2026, Lupin Pharmaceuticals, Inc.).
What does the promethazine label say about tramadol?
Promethazine's label (effective March 13, 2026) does not name tramadol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROMETHAZINE HYDROCHLORIDE), KVK-Tech, Inc., effective March 13, 2026 (SPL set 7a137adf-39b7-4b14-80da-c3cac9ad562a), via openFDA; the full label on DailyMed
What does the tramadol label say about promethazine?
Tramadol Hydrochloride Extended-Release label (Trigen Laboratories, LLC, January 23, 2026), warnings and precautionsConcomitant use of tramadol increases the seizure risk in patients taking: [see Drug Interactions (7) ] Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) antidepressants or anorectics, Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.), O
Tramadol Hydrochloride label (TruPharma, LLC, January 25, 2023), warnings and precautionsSelective serotonin re-uptake inhibitors (SSRI antidepressants or anorectics), Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.), Other opioids, MAO inhibitors [see Warnings and Precautions ( 5.9 ), Drug Interactions ( 7 )].
Source: FDA drug label (Tramadol Hydrochloride Extended-Release, NDA022370), Trigen Laboratories, LLC, effective January 23, 2026 (SPL set c0bc7218-3fd0-4646-96f4-25355fc84aa9), via openFDA
Source: FDA drug label (Tramadol Hydrochloride, NDA214044), TruPharma, LLC, effective January 25, 2023 (SPL set aea56ff9-94ac-47a8-8f15-8790d538973b), via openFDA
Source: FDA drug label (TRAMADOL HYDROCHLORIDE), Lupin Pharmaceuticals, Inc., effective March 5, 2026 (SPL set 46bb9ae6-3ee8-463c-badb-c7a45a89b84b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Promethazine | Tramadol | |
|---|---|---|
| Labeled for | n/a | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0455 per tablet 25 mg tablet | $0.0248 per tablet 50 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once