What the FDA labels say about taking them together
Procainamide and sertraline
Sertraline's FDA label of August 8, 2023 names procainamide in its drug interactions section; the procainamide label PlainMeds reads does not name sertraline.
Check it at the source: the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the procainamide label say about sertraline?
Procainamide's label (effective February 17, 2025) does not name sertraline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
What does the sertraline label say about procainamide?
Sertraline label, drug interactionsClass 1A antiarrhythmic medications (e.g., quinidine, procainamide);
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Procainamide | Sertraline | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once