What the FDA labels say about taking them together
Probenecid and sodium phenylbutyrate
Sodium phenylbutyrate's FDA label of July 17, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name sodium phenylbutyrate.
Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the sodium phenylbutyrate FDA label on DailyMed (effective July 17, 2026, Medunik USA).
What does the probenecid label say about sodium phenylbutyrate?
Probenecid's label (effective January 5, 2021) does not name sodium phenylbutyrate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
What does the sodium phenylbutyrate label say about probenecid?
Sodium phenylbutyrate label, drug interactionsDrugs on PHEBURANE Probenecid Probenecid may inhibit renal excretion of the metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine.
Source: FDA drug label (Olpruva, NDA214860), Acer Therapeutics Inc., effective December 18, 2024 (SPL set 89abc31c-43e8-4809-9eb7-172cb31a86f1), via openFDA
Source: FDA drug label (PHEBURANE), Medunik USA, effective July 17, 2026 (SPL set d15f2cbf-4d22-40b5-8ef9-16b9d323a7f9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid | Sodium phenylbutyrate | |
|---|---|---|
| Labeled for | Gout | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.636 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once