What the FDA labels say about taking them together
Probenecid and sodium benzoate/sodium phenylacetate
Sodium benzoate/sodium phenylacetate's FDA label of December 6, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name sodium benzoate/sodium phenylacetate. The sodium benzoate/sodium phenylacetate label: “DRUG INTERACTIONS Some antibiotics such as penicillin may affect the overall disposition of the infused drug. Probenecid may affect renal excretion of phenylacetylglutamine and hippurate. …”
Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the sodium benzoate/sodium phenylacetate FDA label on DailyMed (effective December 6, 2025).
What does the probenecid label say about sodium benzoate/sodium phenylacetate?
Probenecid's label (effective January 5, 2021) does not name sodium benzoate/sodium phenylacetate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
What does the sodium benzoate/sodium phenylacetate label say about probenecid?
Sodium benzoate/sodium phenylacetate label, drug interactionsDRUG INTERACTIONS Some antibiotics such as penicillin may affect the overall disposition of the infused drug. ( 7 ) Probenecid may affect renal excretion of phenylacetylglutamine and hippurate. ( 7 ) Valproic acid given to patients with urea cycle disorders may exacerbate their condition and antagonize the efficacy of Sodium Phenylacetate and Sodium Benzoate Injection through inhibition of the synthesis of N-acetylglutamate, a co-factor for carbamyl phosphate synthetase. ( 7 ) Use of corticosteroids may cause the breakdown of body protein and potentially increase plasma ammonia levels in patients with impaired ability to form urea. …
Sodium Phenylacetate And Sodium Benzoate label (MAIA PHARMACEUTICALS, January 16, 2023), drug interactionsProbenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate.
Source: FDA drug label (Sodium Phenylacetate And Sodium Benzoate, NDA215025), MAIA PHARMACEUTICALS, effective January 16, 2023 (SPL set ab40b62b-9f8d-4394-92d5-09d9f1941eaa), via openFDA
Source: FDA drug label (Sodium phenylacetate and Sodium benzoate), Navinta LLC, effective December 6, 2025 (SPL set d20768fe-4516-483a-a082-ff1df9ad1d99), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid | Sodium benzoate/sodium phenylacetate | |
|---|---|---|
| Labeled for | Gout | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.636 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once