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What the FDA labels say about taking them together

Probenecid and salicylic acid

Salicylic acid's FDA label of October 22, 2024 names probenecid in its drug interactions (prescription label) section; the probenecid label PlainMeds reads does not name salicylic acid.

Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the salicylic acid FDA label on DailyMed (effective October 22, 2024).

What does the probenecid label say about salicylic acid?

Probenecid's label (effective January 5, 2021) does not name salicylic acid in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed

What does the salicylic acid label say about probenecid?

Salicylic acid label, drug interactions (prescription label)

Drug: Uricosuric Agents; Description: Effect of probenecid, sulfinpyrazone and phenylbutazone inhibited

Source: FDA drug label (bareMinerals Blemish Rescue Skin-Clearing Loose Foundation Fair 1C), Orveon Global US LLC, effective October 22, 2024 (SPL set 139e2d26-76de-4ad3-a6e6-7465bf5987ad), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

6Probenecid generic labelers
0Salicylic acid generic labelers
ProbenecidSalicylic acid
Labeled forGoutAcne, Pain, Psoriasis
Boxed warningNoNo
Pharmacy cost (NADAC)$0.636 per tablet 500 mg tablet$0.102 per patch Callus removers patch
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?