What the FDA labels say about taking them together
Pretomanid and sulfasalazine
Pretomanid's FDA label of November 15, 2024 names sulfasalazine in its drug interactions section; the sulfasalazine label PlainMeds reads does not name pretomanid. The pretomanid label: “Therefore, it cannot be excluded that co-administration of pretomanid with sensitive OATP1B3 substrates (e.g., valsartan, statins), BCRP substrates and P-gp substrates may increase their exposure.”
Check it at the source: the pretomanid FDA label on DailyMed (effective November 15, 2024, Viatris Specialty LLC); the sulfasalazine FDA label on DailyMed (effective May 29, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the pretomanid label say about sulfasalazine?
Pretomanid label, drug interactionsTherefore, it cannot be excluded that co-administration of pretomanid with sensitive OATP1B3 substrates (e.g., valsartan, statins), BCRP substrates (e.g., rosuvastatin, prazosin, glyburide, sulfasalazine) and P-gp substrates (e.g., digoxin, dabigatran etexilate, verapamil) may increase their exposure.
Source: FDA drug label (Pretomanid), NDA212862 (Mylan Ireland Ltd), as published by Viatris Specialty LLC, effective November 15, 2024 (SPL set f1906fc9-cb3c-4e13-8a4a-da76100c1bf3), via openFDA; the full label on DailyMed
What does the sulfasalazine label say about pretomanid?
Sulfasalazine's label (effective May 29, 2026) does not name pretomanid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Azulfidine), Pfizer Laboratories Div Pfizer Inc, effective May 29, 2026 (SPL set ddbe69f3-bd55-45f3-a64f-f60226c744c4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pretomanid | Sulfasalazine | |
|---|---|---|
| Labeled for | n/a | Crohn's disease and ulcerative colitis, Rheumatoid arthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.199 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once