What the FDA labels say about taking them together
Pralatrexate and probenecid
Pralatrexate's FDA label of November 15, 2022 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name pralatrexate. The pralatrexate label: “DRUG INTERACTIONS Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs.”
Check it at the source: the pralatrexate FDA label on DailyMed (effective November 15, 2022, Fresenius Kabi USA, LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the pralatrexate label say about probenecid?
Pralatrexate label, drug interactionsDRUG INTERACTIONS Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs.
Source: FDA drug label (Pralatrexate), NDA022468 (Acrotech Biopharma), as published by Fresenius Kabi USA, LLC, effective November 15, 2022 (SPL set a5daa583-4965-4564-ad87-41ffe6c08a11), via openFDA; the full label on DailyMed
What does the probenecid label say about pralatrexate?
Probenecid's label (effective January 5, 2021) does not name pralatrexate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pralatrexate | Probenecid | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once