Potassium Citrate and Eplerenone Interaction
Drug interaction information between Potassium Citrate and Eplerenone.
Potassium Citrate and Eplerenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Citrate and Eplerenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Eplerenone changes how your body handles minerals, making it harder for your kidneys to flush out extra potassium.
FDA Label Information
7.3 Renin-Angiotensin-Aldosterone System Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Potassium Citrate Also Interacts With
- Spironolactone minor
- Amiloride minor
- Aliskiren minor
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
Frequently Asked Questions
What SPL severity band is on file for Potassium Citrate + Eplerenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Eplerenone has 12 labeled pairs on file vs Potassium Citrate's 4. In the minor band specifically: Potassium Citrate has 4 (also Spironolactone, Amiloride, Aliskiren); Eplerenone has 7 (also Lithium, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide).
What mechanism field is on file for Potassium Citrate and Eplerenone?
Eplerenone changes how your body handles minerals, making it harder for your kidneys to flush out extra potassium.
Eplerenone carries more major-labeled pairs than Potassium Citrate
SPL source-record counts only. This page's band is minor · classes on file: Potassium Citrate (Urinary Alkalinizer); Eplerenone (Aldosterone Antagonist).
Eplerenone has 5 major-labeled pairs vs Potassium Citrate's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Potassium Citrate
- Spironolactone
- Amiloride
- Aliskiren
5 major · 0 moderate · 7 minor · 12 total
- Other minor peers for Eplerenone
- Lithium
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.