Potassium Citrate and Amiloride Interaction
Drug interaction information between Potassium Citrate and Amiloride.
Potassium Citrate and Amiloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Citrate and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiloride prevents the kidneys from removing potassium, and taking it with a potassium supplement can cause levels to rise too high.
FDA Label Information
7 DRUG INTERACTIONS The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) Drugs that slow gastrointestinal transit time: These agents (such as anticholinergics) can be expected to increase the gastrointestinal irritation produced by potassium salts (7.2) Renin-angiotensin-aldosterone inhibitors: Monitor for hyperkalemia (7.3) Nonsteroidal Anti-inflammatory drugs (NSAIDs) monitor for hyperkalemia (7.4) 7.1 Potential...
Potassium Citrate Also Interacts With
- Spironolactone minor
- Eplerenone minor
- Aliskiren minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Potassium Citrate + Amiloride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Potassium Citrate's 4. In the minor band specifically: Potassium Citrate has 4 (also Spironolactone, Eplerenone, Aliskiren); Amiloride has 11 (also Indomethacin, Amlodipine/Valsartan, Enalapril, Hydrochlorothiazide).
What mechanism field is on file for Potassium Citrate and Amiloride?
Amiloride prevents the kidneys from removing potassium, and taking it with a potassium supplement can cause levels to rise too high.
Amiloride carries more major-labeled pairs than Potassium Citrate
SPL source-record counts only. This page's band is minor · classes on file: Potassium Citrate (Urinary Alkalinizer); Amiloride (Potassium-Sparing Diuretic).
Amiloride has 1 major-labeled pair vs Potassium Citrate's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Potassium Citrate
- Spironolactone
- Eplerenone
- Aliskiren
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Amlodipine/Valsartan
- Enalapril
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.