What the FDA labels say about taking them together
Amiloride and potassium citrate
Potassium citrate's FDA label of December 2, 2021 names amiloride in its contraindications section; the amiloride label PlainMeds reads does not name potassium citrate. The potassium citrate label: “Concomitant administration of Urocit-K and a potassium-sparing diuretic should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia.”
Check it at the source: the amiloride FDA label on DailyMed (effective May 5, 2023, Padagis US LLC); the potassium citrate FDA label on DailyMed (effective December 2, 2021, Mission Pharmacal Company).
What does the amiloride label say about potassium citrate?
Amiloride's label (effective May 5, 2023) does not name potassium citrate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (amiloride hydrochloride), Padagis US LLC, effective May 5, 2023 (SPL set 2b70cf0c-45be-428f-b396-5001ed4e30fc), via openFDA; the full label on DailyMed
What does the potassium citrate label say about amiloride?
Potassium citrate label, contraindicationsSuch conditions include: chronic renal failure, uncontrolled diabetes mellitus, acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown or the administration of a potassium-sparing agent (such as triamterene, spironolactone or amiloride).
Potassium citrate label, drug interactionsConcomitant administration of Urocit-K and a potassium-sparing diuretic (such as triamterene, spironolactone or amiloride) should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia.
Source: FDA drug label (UROCIT-K), Mission Pharmacal Company, effective December 2, 2021 (SPL set 72cdea1b-2240-41db-987d-86d5c6aaa978), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiloride | Potassium citrate | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.190 per tablet 5 mg tablet | $0.175 per tablet 10 mEq tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once