What the FDA labels say about taking them together
Cyclosporine and piroxicam
Cyclosporine's FDA label of August 10, 2026 names piroxicam in its drug interactions section, and piroxicam's label names cyclosporine too. The piroxicam label: “Concomitant use of piroxicam and cyclosporine may increase cyclosporine’s nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the piroxicam FDA label on DailyMed (effective August 19, 2026, Teva Pharmaceuticals USA, Inc.).
What does the cyclosporine label say about piroxicam?
Cyclosporine label, drug interactionsNo clinically significant pharmacokinetic interactions occurred between cyclosporine and aspirin, ketoprofen, piroxicam, or indomethacin.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the piroxicam label say about cyclosporine?
Piroxicam label, drug interactionsClinical Impact: Concomitant use of piroxicam and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of piroxicam and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Source: FDA drug label (Piroxicam), Teva Pharmaceuticals USA, Inc., effective August 19, 2026 (SPL set f1123fe1-b79c-430b-8548-08cd6e518482), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Piroxicam | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.215 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once