What the FDA labels say about taking them together
Phenytoin and praziquantel
Phenytoin's FDA label of October 15, 2024 names praziquantel in its drug interactions section; the praziquantel label PlainMeds reads does not name phenytoin. The phenytoin label: “Interacting Agent: Other; Examples: Albendazole, chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine”
Check it at the source: the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.); the praziquantel FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the phenytoin label say about praziquantel?
Phenytoin label, drug interactionsInteracting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What does the praziquantel label say about phenytoin?
Praziquantel's label (effective March 2, 2026) does not name phenytoin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Biltricide), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 34ce1cdd-648e-4f1e-8512-bf3d4cc22eb9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenytoin | Praziquantel | |
|---|---|---|
| Labeled for | Seizures and epilepsy | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.145 per capsule 100 mg capsule | $53.25 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once