What the FDA labels say about taking them together
Paroxetine and phenytoin
Paroxetine's FDA label (Brisdelle) of April 28, 2025 names phenytoin in its drug interactions section, and phenytoin's label names paroxetine too. The paroxetine label: “Concomitant Drug Name: Phenytoin; Effect of Concomitant Drug on Paroxetine: Decreased paroxetine exposure”
Check it at the source: the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the paroxetine label say about phenytoin?
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsConcomitant Drug Name: Phenytoin; Effect of Concomitant Drug on Paroxetine: Decreased paroxetine exposure
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
What does the phenytoin label say about paroxetine?
Phenytoin label, drug interactionsInteracting Agent: Other; Examples: Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paroxetine | Phenytoin | |
|---|---|---|
| Labeled for | Depression, Anxiety, Menopause symptoms | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0611 per tablet 20 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once