What the FDA labels say about taking them together
Perphenazine and sertraline
Perphenazine's FDA label of December 12, 2024 names sertraline in its drug interactions section, and sertraline's label names perphenazine too. The sertraline label: “ZOLOFT is a CYP2D6 inhibitor. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate.”
Check it at the source: the perphenazine FDA label on DailyMed (effective December 12, 2024, Rising Pharma Holdings, Inc.); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the perphenazine label say about sertraline?
Perphenazine label, drug interactionsAmong these are tricyclic antidepressants and selective serotonin reuptake inhibitors, e.g., fluoxetine, sertraline and paroxetine.
Source: FDA drug label (PERPHENAZINE), Rising Pharma Holdings, Inc., effective December 12, 2024 (SPL set 0ebf4c11-1810-42f6-a8e3-071616e33d5d), via openFDA; the full label on DailyMed
What does the sertraline label say about perphenazine?
Sertraline label, drug interactionsDrugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Perphenazine | Sertraline | |
|---|---|---|
| Labeled for | Schizophrenia, Nausea and vomiting | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.161 per tablet 4 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once