What the FDA labels say about taking them together
Perphenazine and phenelzine
Phenelzine's FDA label of June 6, 2025 names perphenazine in its warnings section; the perphenazine label PlainMeds reads does not name phenelzine.
Check it at the source: the perphenazine FDA label on DailyMed (effective December 12, 2024, Rising Pharma Holdings, Inc.); the phenelzine FDA label on DailyMed (effective June 6, 2025, Parke-Davis Div of Pfizer Inc).
What does the perphenazine label say about phenelzine?
Perphenazine's label (effective December 12, 2024) does not name phenelzine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PERPHENAZINE), Rising Pharma Holdings, Inc., effective December 12, 2024 (SPL set 0ebf4c11-1810-42f6-a8e3-071616e33d5d), via openFDA; the full label on DailyMed
What does the phenelzine label say about perphenazine?
Phenelzine label, warningsA List of Dibenzazepine Derivative Drugs by Generic Name Follows: nortriptyline hydrochloride amitriptyline hydrochloride perphenazine and amitriptyline hydrochloride clomipramine hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine NARDIL should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result.
Source: FDA drug label (Nardil), Parke-Davis Div of Pfizer Inc, effective June 6, 2025 (SPL set 513a41d0-37d4-4355-8a6d-a2c643bce6fa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Perphenazine | Phenelzine | |
|---|---|---|
| Labeled for | Schizophrenia, Nausea and vomiting | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.161 per tablet 4 mg tablet | $0.586 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once