What the FDA labels say about taking them together
Perindopril and triamterene
Perindopril's FDA label of March 13, 2024 names triamterene in its drug interactions section; triamterene's label does not name perindopril itself but warns about its class (ACE inhibitors). The perindopril label: “Use of potassium-sparing diuretics, potassium supplements or other drugs capable of increasing serum potassium can increase the risk of hyperkalemia.”
Check it at the source: the perindopril FDA label on DailyMed (effective March 13, 2024, Aurobindo Pharma Limited); the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the perindopril label say about triamterene?
Perindopril label, drug interactionsUse of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Source: FDA drug label (Perindopril Erbumine), Aurobindo Pharma Limited, effective March 13, 2024 (SPL set 87768fbf-7c63-47da-8925-0316f343d6ef), via openFDA; the full label on DailyMed
What does the triamterene label say about perindopril?
Triamterene's label does not name perindopril itself; it warns about its class (ACE inhibitors):
Triamterene label, drug interactionsPotassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to an increased risk of hyperkalemia.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Perindopril | Triamterene | |
|---|---|---|
| Labeled for | High blood pressure, Heart attack and coronary artery disease | Heart failure, Edema (fluid retention) |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.495 per tablet 4 mg tablet | $5.98 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once