Perindopril and Lithium Interaction
Drug interaction information between Perindopril and Lithium.
Perindopril and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Perindopril and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Perindopril can make it harder for your body to get rid of lithium. This causes lithium to build up in your blood, which can lead to dangerous side effects.
FDA Label Information
(7.2) Lithium: Increase serum lithium levels, symptoms of lithium toxicity. 7.3 Lithium Increased serum lithium and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. Frequent monitoring of serum lithium concentration is recommended.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Perindopril's 9. In the minor band specifically: Perindopril has 3 (also Gentamicin, Digoxin); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Perindopril and Lithium?
Perindopril can make it harder for your body to get rid of lithium. This causes lithium to build up in your blood, which can lead to dangerous side effects.
Lithium carries more major-labeled pairs than Perindopril
SPL source-record counts only. This page's band is minor · classes on file: Perindopril (ACE Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Perindopril's 1. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other minor peers for Perindopril
- Gentamicin
- Digoxin
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.