What the FDA labels say about taking them together
Pentobarbital and warfarin
Pentobarbital's FDA label of March 8, 2024 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name pentobarbital. The pentobarbital label: “Barbiturates can induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response of oral anticoagulants.”
Check it at the source: the pentobarbital FDA label on DailyMed (effective March 8, 2024, Hikma Pharmaceuticals USA Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the pentobarbital label say about warfarin?
Pentobarbital label, drug interactionsBarbiturates can induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response of oral anticoagulants (e.g., warfarin, acenocoumarol, dicumarol, and phenprocoumon).
Source: FDA drug label (Pentobarbital Sodium), Hikma Pharmaceuticals USA Inc., effective March 8, 2024 (SPL set d375b92a-baa1-4d63-9ad1-1467dcfde7d5), via openFDA; the full label on DailyMed
What does the warfarin label say about pentobarbital?
Warfarin's label (effective May 29, 2026) does not name pentobarbital in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pentobarbital | Warfarin | |
|---|---|---|
| Labeled for | Insomnia | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once