What the FDA labels say about taking them together
Pemetrexed and piroxicam
Piroxicam's FDA label of August 19, 2026 names pemetrexed in its drug interactions section; the pemetrexed labels PlainMeds reads (4) do not name piroxicam. The piroxicam label: “Concomitant use of piroxicam and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.”
Check it at the source: the pemetrexed FDA label on DailyMed (effective October 8, 2025, Avyxa Pharma, LLC); the piroxicam FDA label on DailyMed (effective August 19, 2026, Teva Pharmaceuticals USA, Inc.).
What does the pemetrexed label say about piroxicam?
Pemetrexed's label (effective October 8, 2025) and its 3 other brand-application labels do not name piroxicam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AXTLE), Avyxa Pharma, LLC, effective October 8, 2025 (SPL set 9582c46c-d8b0-44b7-a2ee-9c86f5e9b7b1), via openFDA; the full label on DailyMed
What does the piroxicam label say about pemetrexed?
Piroxicam label, drug interactionsPemetrexed Clinical Impact: Concomitant use of piroxicam and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (…). Intervention: During concomitant use of piroxicam and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. …
Source: FDA drug label (Piroxicam), Teva Pharmaceuticals USA, Inc., effective August 19, 2026 (SPL set f1123fe1-b79c-430b-8548-08cd6e518482), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pemetrexed | Piroxicam | |
|---|---|---|
| Labeled for | Lung cancer | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.215 per capsule 20 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once