What the FDA labels say about taking them together
Pantoprazole and warfarin
Pantoprazole's FDA label of May 18, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name pantoprazole. The pantoprazole label: “Increased INR and prothrombin time in patients receiving PPIs, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death.”
Check it at the source: the pantoprazole FDA label on DailyMed (effective May 18, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the pantoprazole label say about warfarin?
Pantoprazole label, drug interactionsClinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Intervention: Monitor INR and prothrombin time. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Pantoprazole Sodium label (Hikma Pharmaceuticals USA Inc., July 19, 2023), drug interactionsWarfarin C linical Impact: Increased INR and prothrombin time in patients receiving PPIs, including pantoprazole, and warfarin concomitantly.
Source: FDA drug label (Pantoprazole Sodium, NDA209463), Hikma Pharmaceuticals USA Inc., effective July 19, 2023 (SPL set 1e102c44-232b-4aaf-b457-2a740c47193a), via openFDA
Source: FDA drug label (Protonix Delayed-Release), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective May 18, 2026 (SPL set 08098cb2-c048-4640-f387-6beec4a38936), via openFDA; the full label on DailyMed
What does the warfarin label say about pantoprazole?
Warfarin's label (effective May 29, 2026) does not name pantoprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pantoprazole | Warfarin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0358 per tablet 40 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once