Oxaprozin and Cyclosporine Interaction
Drug interaction information between Oxaprozin and Cyclosporine.
Oxaprozin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxaprozin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxaprozin can increase the harmful effects that cyclosporine has on the kidneys. This occurs because both drugs can reduce the blood flow that helps the kidneys function properly.
FDA Label Information
Cyclosporine Clinical Impact: Concomitant use of COXANTO and cyclosporine may increase cyclosporine's nephrotoxicity. Intervention: During concomitant use of COXANTO and cyclosporine, monitor patients for signs of worsening renal function.
Oxaprozin Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Oxaprozin + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Oxaprozin's 15. In the minor band specifically: Oxaprozin has 11 (also Meloxicam, Aspirin, Propranolol, Diclofenac); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Oxaprozin and Cyclosporine?
Oxaprozin can increase the harmful effects that cyclosporine has on the kidneys. This occurs because both drugs can reduce the blood flow that helps the kidneys function properly.
Cyclosporine carries more major-labeled pairs than Oxaprozin
SPL source-record counts only. This page's band is minor · classes on file: Oxaprozin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Oxaprozin's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Oxaprozin
- Meloxicam
- Aspirin
- Propranolol
- Diclofenac
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.