What the FDA labels say about taking them together
Orlistat and warfarin
Orlistat's FDA label of March 18, 2026 names warfarin in its drug interactions (prescription label) section; the warfarin label PlainMeds reads does not name orlistat. The orlistat label: “Patients on chronic stable doses of warfarin who are prescribed XENICAL should be monitored closely for changes in coagulation parameters.”
Check it at the source: the orlistat FDA label on DailyMed (effective March 18, 2026, Haleon US Holdings LLC); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the orlistat label say about warfarin?
Orlistat label, drug interactions (prescription label)Patients on chronic stable doses of warfarin who are prescribed XENICAL should be monitored closely for changes in coagulation parameters.
Orlistat label, warnings and precautions (prescription label)Interactions and Decreased Vitamin Absorption XENICAL may interact with concomitant drugs including cyclosporine, levothyroxine, warfarin, amiodarone, antiepileptic drugs, and antiretroviral drugs [see Drug Interactions (7) ].
Source: FDA drug label (ALLI), Haleon US Holdings LLC, effective March 18, 2026 (SPL set a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f), via openFDA; the full label on DailyMed
What does the warfarin label say about orlistat?
Warfarin's label (effective May 29, 2026) does not name orlistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Orlistat | Warfarin | |
|---|---|---|
| Labeled for | Weight management | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $7.00 per capsule 120 mg capsule | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once