What the FDA labels say about taking them together
Oliceridine and phenytoin
Oliceridine's FDA label of December 31, 2025 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name oliceridine. The oliceridine label: “The concomitant use of OLINVYK and CYP3A4 inducers can decrease the plasma concentration of oliceridine, resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical …”
Check it at the source: the oliceridine FDA label on DailyMed (effective December 31, 2025, Trevena, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the oliceridine label say about phenytoin?
Oliceridine label, drug interactionsInducers of CYP3A4 Clinical Impact: The concomitant use of OLINVYK and CYP3A4 inducers can decrease the plasma concentration of oliceridine, resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to oliceridine.. … OLINVYK dosage reduction and monitor for signs of respiratory depression. Examples: Rifampin, carbamazepine, phenytoin
Source: FDA drug label (OLINVYK), Trevena, Inc., effective December 31, 2025 (SPL set ce167984-8b9d-40b7-84ce-d0f33fff1eaa), via openFDA; the full label on DailyMed
What does the phenytoin label say about oliceridine?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name oliceridine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Oliceridine | Phenytoin | |
|---|---|---|
| Labeled for | Pain | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once