What the FDA labels say about taking them together
Olanzapine and quetiapine
Quetiapine's FDA label of April 10, 2026 names olanzapine in its warnings and precautions section; olanzapine's label does not name quetiapine itself but warns about its class (Atypical antipsychotics).
Check it at the source: the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited); the quetiapine FDA label on DailyMed (effective April 10, 2026, H2-Pharma, LLC).
What does the olanzapine label say about quetiapine?
Olanzapine's label does not name quetiapine itself; it warns about its class (Atypical antipsychotics):
Olanzapine label, boxed warningAnalyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients.
Olanzapine label, boxed warningINCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
What does the quetiapine label say about olanzapine?
Quetiapine label, warnings and precautionsPatients with Dementia-Related Psychosis In placebo-controlled trials with risperidone, aripiprazole, and olanzapine in elderly subjects with dementia, there was a higher incidence of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) including fatalities compared to placebo-treated subjects.
Source: FDA drug label (SEROQUEL), NDA020639 (Cheplapharm), as published by H2-Pharma, LLC, effective April 10, 2026 (SPL set 8ae62aaf-f8c5-417f-baac-0098369ca322), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Olanzapine | Quetiapine | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.147 per tablet 20 mg tablet | $0.127 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once