What the FDA labels say about taking them together
Fluvoxamine and olanzapine
Olanzapine's FDA label of March 5, 2026 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name olanzapine. The olanzapine label: “Increased clearance of olanzapine. Fluvoxamine: May increase olanzapine levels.”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited).
What does the fluvoxamine label say about olanzapine?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name olanzapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the olanzapine label say about fluvoxamine?
Olanzapine label, drug interactionsInhibitors of CYP1A2 Fluvoxamine: Fluvoxamine, a CYP1A2 inhibitor, decreases the clearance of olanzapine.
Zyprexa label (H2-Pharma LLC, February 11, 2026), drug interactionsIncreased clearance of olanzapine. ( 7.1 ) Fluvoxamine: May increase olanzapine levels. ( 7.1 ) ZYPREXA and Fluoxetine in Combination:
Zyprexa Relprevv label (H2-Pharma LLC, May 19, 2026), drug interactionsIncreased clearance of olanzapine. ( 7.1 ) Fluvoxamine: May increase olanzapine levels.
Source: FDA drug label (Zyprexa, NDA020592), H2-Pharma LLC, effective February 11, 2026 (SPL set b418946a-1ab4-4d89-a012-d94fc361a3c4), via openFDA
Source: FDA drug label (Zyprexa Relprevv, NDA022173), H2-Pharma LLC, effective May 19, 2026 (SPL set 11544cba-64a9-49cb-8d74-da228053b252), via openFDA
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Olanzapine | |
|---|---|---|
| Labeled for | n/a | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | $0.147 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once