What the FDA labels say about taking them together
Ofloxacin and warfarin
Ofloxacin's FDA label (Ocuflox) of June 13, 2024 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name ofloxacin. The ofloxacin label: “… metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine …”
Check it at the source: the ofloxacin FDA label on DailyMed (effective July 18, 2024, Amneal Pharmaceuticals NY LLC); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the ofloxacin label say about warfarin?
Ocuflox label (Allergan, Inc., June 13, 2024), drug interactionsHowever, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Source: FDA drug label (Ocuflox, NDA019921), Allergan, Inc., effective June 13, 2024 (SPL set 7aab4449-3dda-4e2c-8e40-b3244a548bf5), via openFDA
Source: FDA drug label (Ofloxacin), Amneal Pharmaceuticals NY LLC, effective July 18, 2024 (SPL set ba37e2a0-1bf7-41ca-bddd-35fcb77f87de), via openFDA; the full label on DailyMed
What does the warfarin label say about ofloxacin?
Warfarin's label (effective May 29, 2026) does not name ofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ofloxacin | Warfarin | |
|---|---|---|
| Labeled for | Bacterial infections | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.24 per mL 0.3% eye drops | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once