What the FDA labels say about taking them together
Norepinephrine and protriptyline
Norepinephrine's FDA label of June 12, 2025 names protriptyline in its drug interactions section; the protriptyline label PlainMeds reads does not name norepinephrine.
Check it at the source: the norepinephrine FDA label on DailyMed (effective June 12, 2025, Hospira, Inc.); the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC).
What does the norepinephrine label say about protriptyline?
Norepinephrine label, drug interactionsTricyclic Antidepressants Co-administration of LEVOPHED with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Norepinephrine Bitartrate label (Baxter Healthcare Corporation, February 6, 2026), drug interactionsBitartrate in Dextrose Injection or Norepinephrine Bitartrate in Sodium Chloride Injection with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Source: FDA drug label (Norepinephrine Bitartrate, NDA214313), Baxter Healthcare Corporation, effective February 6, 2026 (SPL set 6363e9b4-29df-4553-904d-a563e5adda6e), via openFDA
Source: FDA drug label (Norepinephrine, NDA214628), Long Grove Pharmaceuticals, LLC, effective December 4, 2025 (SPL set 759807dd-61a8-4f6f-8bf5-f6ee773c81bc), via openFDA
Source: FDA drug label (Norepinephrine Bitartrate In Sodium Chloride, NDA215700), WG Critical Care, LLC, effective February 17, 2026 (SPL set ddbef60d-c20a-4ada-928f-e87074c08a54), via openFDA
Source: FDA drug label (LEVOPHED), Hospira, Inc., effective June 12, 2025 (SPL set 2c7dd2b0-cc10-4db6-bf56-6eb154ebeb10), via openFDA; the full label on DailyMed
What does the protriptyline label say about norepinephrine?
Protriptyline's label (effective July 25, 2023) does not name norepinephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Norepinephrine | Protriptyline | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $2.71 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once