What the FDA labels say about taking them together
Nitric oxide and vardenafil
Vardenafil's FDA label of January 5, 2026 names nitric oxide in its contraindications section; the nitric oxide labels PlainMeds reads (2) do not name vardenafil. The vardenafil label: “Interactions with Vardenafil Nitrates Concomitant use of vardenafil and nitrates and nitric oxide donors is contraindicated.”
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the vardenafil FDA label on DailyMed (effective January 5, 2026, Zydus Pharmaceuticals USA Inc.).
What does the nitric oxide label say about vardenafil?
Nitric oxide's label (effective December 11, 2025) and its 1 other brand-application label do not name vardenafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the vardenafil label say about nitric oxide?
Vardenafil label, contraindicationsCONTRAINDICATIONS Administration with nitrates and nitric oxide donors ( 2.4 , 4.1 ) Administration with guanylate cyclase (GC) stimulators, such as riociguat
Vardenafil label, drug interactionsInteractions with Vardenafil Nitrates Concomitant use of vardenafil and nitrates and nitric oxide donors is contraindicated.
Source: FDA drug label (VARDENAFIL), Zydus Pharmaceuticals USA Inc., effective January 5, 2026 (SPL set 5876e062-e604-42a7-99c3-5da30b8dac06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Vardenafil | |
|---|---|---|
| Labeled for | n/a | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $2.79 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once