What the FDA labels say about taking them together
Nitric oxide and tadalafil
Tadalafil's FDA label (Adcirca) of December 15, 2025 names nitric oxide in its contraindications section; the nitric oxide labels PlainMeds reads (2) do not name tadalafil.
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the nitric oxide label say about tadalafil?
Nitric oxide's label (effective December 11, 2025) and its 1 other brand-application label do not name tadalafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the tadalafil label say about nitric oxide?
Adcirca label (United Therapeutics Corporation, December 15, 2025), contraindicationsThis potentiation is thought to result from the combined effects of nitrates and ADCIRCA on the nitric oxide/cGMP pathway [see Clinical Pharmacology ( 12.2 )].
Source: FDA drug label (Adcirca, NDA022332), United Therapeutics Corporation, effective December 15, 2025 (SPL set ff61b237-be8e-461b-8114-78c52a8ad0ae), via openFDA
Source: FDA drug label (Tadliq, NDA214522), CMP Pharma, Inc., effective October 15, 2022 (SPL set 7a909b25-3772-403e-a5fe-e4a040293fb7), via openFDA
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Tadalafil | |
|---|---|---|
| Labeled for | n/a | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.167 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once