What the FDA labels say about taking them together
Nitric oxide and sodium nitroprusside
Nitric oxide's FDA label of December 11, 2025 names sodium nitroprusside in its drug interactions section; the sodium nitroprusside labels PlainMeds reads (2) do not name nitric oxide. The nitric oxide label: “Nitric oxide donor agents such as prilocaine, sodium nitroprusside and nitroglycerine may increase the risk of developing methemoglobinemia.”
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the sodium nitroprusside FDA label on DailyMed (effective August 10, 2026, Micro Labs Limited).
What does the nitric oxide label say about sodium nitroprusside?
Nitric oxide label, drug interactionsNitric oxide donor agents such as prilocaine, sodium nitroprusside and nitroglycerine may increase the risk of developing methemoglobinemia.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the sodium nitroprusside label say about nitric oxide?
Sodium nitroprusside's label (effective August 10, 2026) and its 1 other brand-application label do not name nitric oxide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SODIUM NITROPRUSSIDE), Micro Labs Limited, effective August 10, 2026 (SPL set 5a599880-c133-44ef-a9f2-bd1b681563be), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Sodium nitroprusside | |
|---|---|---|
| Labeled for | n/a | Heart failure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once