What the FDA labels say about taking them together
Nitric oxide and sodium nitrite
Sodium nitrite's FDA label of October 6, 2025 names nitric oxide in its warnings and precautions section; the nitric oxide labels PlainMeds reads (2) do not name sodium nitrite. The sodium nitrite label: “Use sodium nitrite with caution in the presence of concomitant antihypertensive medications, diuretics or volume depletion due to diuretics, or drugs known to increase vascular nitric oxide, such as PDE5 inhibitors.”
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the sodium nitrite FDA label on DailyMed (effective October 6, 2025, Hope Pharmaceuticals).
What does the nitric oxide label say about sodium nitrite?
Nitric oxide's label (effective December 11, 2025) and its 1 other brand-application label do not name sodium nitrite in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the sodium nitrite label say about nitric oxide?
Sodium nitrite label, warnings and precautionsUse sodium nitrite with caution in the presence of concomitant antihypertensive medications, diuretics or volume depletion due to diuretics, or drugs known to increase vascular nitric oxide, such as PDE5 inhibitors.
Source: FDA drug label (Sodium Nitrite), Hope Pharmaceuticals, effective October 6, 2025 (SPL set 52f01c6e-172a-47a9-98a6-9eab7651a032), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Sodium nitrite | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once