What the FDA labels say about taking them together
Nitric oxide and riociguat
Riociguat's FDA label of August 13, 2026 names nitric oxide in its contraindications section; the nitric oxide labels PlainMeds reads (2) do not name riociguat. The riociguat label: “Adempas with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated.”
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the riociguat FDA label on DailyMed (effective August 13, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the nitric oxide label say about riociguat?
Nitric oxide's label (effective December 11, 2025) and its 1 other brand-application label do not name riociguat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the riociguat label say about nitric oxide?
Riociguat label, contraindicationsAdempas with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated [see Drug Interactions (7.1) and Clinical Pharmacology (12.2) ].
Source: FDA drug label (Adempas), Bayer HealthCare Pharmaceuticals Inc., effective August 13, 2026 (SPL set 7b57509a-3d5d-41d4-8fed-1471e26372a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Riociguat | |
|---|---|---|
| Labeled for | n/a | Pulmonary arterial hypertension |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once