What the FDA labels say about taking them together
Nitric oxide and prilocaine
Nitric oxide's FDA label of December 11, 2025 names prilocaine in its drug interactions section, and prilocaine's label names nitric oxide too. The nitric oxide label: “Nitric oxide donor agents such as prilocaine, sodium nitroprusside and nitroglycerine may increase the risk of developing methemoglobinemia.”
Check it at the source: the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.); the prilocaine FDA label on DailyMed (effective November 10, 2021, Dentsply Pharmaceutical Inc.).
What does the nitric oxide label say about prilocaine?
Nitric oxide label, drug interactionsNitric oxide donor agents such as prilocaine, sodium nitroprusside and nitroglycerine may increase the risk of developing methemoglobinemia.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
What does the prilocaine label say about nitric oxide?
Prilocaine label, drug interactionsClass: Nitrates/Nitrites; Examples: nitric oxide, nitroglycerin, nitroprusside, nitrous oxide
Source: FDA drug label (Citanest Plain), ANDA079235 (Septodont Inc), as published by Dentsply Pharmaceutical Inc., effective November 10, 2021 (SPL set db23a56f-1e41-4843-9220-1b2e3059db41), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitric oxide | Prilocaine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once