What the FDA labels say about taking them together
Nisoldipine and propranolol
Nisoldipine's FDA label of March 12, 2026 names propranolol in its drug interactions section, and propranolol's label names nisoldipine too. The propranolol label: “Calcium Channel Blockers The mean C max and AUC of propranolol are increased, respectively, by 50% and 30% by co-administration of nisoldipine and by 80% and 47%, by co-administration of nicardipine.”
Check it at the source: the nisoldipine FDA label on DailyMed (effective March 12, 2026, Covis Pharma US, Inc); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the nisoldipine label say about propranolol?
Nisoldipine label, drug interactionsPharmacokinetic interactions between nisoldipine and beta-blockers (atenolol, propranolol) were variable and not significant.
Source: FDA drug label (Sular), NDA020356 (Azurity), as published by Covis Pharma US, Inc, effective March 12, 2026 (SPL set 589157fa-d129-4de3-be3d-e0e1c22c5873), via openFDA; the full label on DailyMed
What does the propranolol label say about nisoldipine?
Propranolol label, drug interactionsCalcium Channel Blockers The mean C max and AUC of propranolol are increased, respectively, by 50% and 30% by co-administration of nisoldipine and by 80% and 47%, by co-administration of nicardipine.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nisoldipine | Propranolol | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $5.24 per tablet 34 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once